Example: In [11]: d0 = pd.to_datetime(pd.Series(["12/1/2011"])) In [12]: d1 = pd.to_datetime(pd.Series(["12/3/2011"])) In [13]: d1[0] - d0[0] Out[13]: datetime.timedelta(2) In [14]: (d1 - d0)[0] Out[14]: 2000 days, 0:00:00