The article explains the significance of size_t and ptrdiff_t types in C/C++ programming, particularly in the context of developing 64-bit applications where they enhance performance and portability. It highlights the pitfalls of using types like int and unsigned for address arithmetic, leading to potential errors, and advocates for the correct usage of size_t and ptrdiff_t to avoid such issues. Additionally, it discusses the gradual process of refactoring existing code to incorporate these types effectively.