Zalando effectively manages Kubernetes clusters on AWS, operating 140 clusters across 396 accounts as of 2019, facilitating over 1,100 developers. The company adopts a 'you build it, you run it' philosophy, emphasizing developer responsibility for software operations and reliability without manual interventions. Their architecture prioritizes autoscaling, cost-efficiency, and streamlined upgrade processes while maintaining a strong focus on automated testing and compliance for production deployments.