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Physics, Chemistry and Living Systems

Introductory lecture

Speaker:
Dr. Ruben Tikidji-Hamburyan


Summer school AACIMP-2010,
Kyiv, KPI, August, 4
Main ideas of program formation
Physics, Chemistry and Living Systems




    Actuality and novelty
    Diversity
    Quality
    of topics, fields, approaches, teaching methods, studying etc.
Stream courses:
Physics, Chemistry and Living Systems

1.  Introduction to modern methods and tools for biologically             plausible
    modeling of neurons and neural networks (Lectures - 4 h., Practice activity – 4 h.),
    Dr. R. Tikidji-Hamburyan
2. Brain–computer interface. Approaches and methods (3 h.), Dr. T. Aksenova
3. Problems of synchronization and presentation of space and time in neural
    networks (10 h.), Prof. Witali L. Dunin-Barkowski
4. Models of synaptic transmission (4 h.), Dr. D. Bibichkov
5. Neuron Connection With Computer in Dynamic-Clamp Experiments (2 h.), Dr.
    A. Chizhov
6. Models of Neuron Populations (2 h.), Dr. A. Chizhov
7. Urgent Questions of Virology (1 h.), Dr. Z. Klestova
8. Visual Cortex (3 h.), Dr. D. Bibichkov&Dr. A. Chizhov
9. Chemoinformatics (2 h.), Dr. I. Tetko
10. Experimental Diagnostics of Our Universe (2 h.), Dr. E. Podladchikova
11. Open Discussion : The Open Questions in Neuroscience (3 h)
     Total hours: 40
Stream information
Physics, Chemistry and Living Systems

 Stream language: English
 Stream rooms:
      40(3), build.#1,
      258 of build.#1 and 235 of build.#3 for practice work
 Plenary lectures at the stream program:
    Presentation of EURO XXV conference in Vilnius,
     Prof. L. Sakalauskas
    P&G master-class on logistics
    Innovation technologies of 3D-modelling, Materialize
 The Open Questions in Neuroscience (Open Discussion),
  Conference hall of Scientific Park, build.#6, 11.08.10
Physics, Chemistry and Living Systems

Teachers and courses
Countries and Universities
Physics, Chemistry and Living Systems




  Southern Federal University,   Max Planck Institute for Biophysical
  Rostov-on-Don, Rusiia          Chemistry, Germany




 CEA, Atomic Energy Center,      Ioffe Physical-Technical Institute of the
 Grenoble, France.               Russian Academy of Sciences
Countries and Universities
Physics, Chemistry and Living Systems




  Royal Observatory of Belgium,
  Solar-Terrestrial Center of Excellence,
  Belgium.


                                            The Institute of Veterinary
                                            Medicine of UAAS, Ukraine.


 Institute of Bioinformatics and Systems Biology, German Research
 Center for Environmental Health, Munich, Germany
Astrophysics
Physics, Chemistry and Living Systems
                    Organizations:
                    Royal Observatory of Belgium, Solar-Terrestrial Center of Excellence,
                    Belgium
                    Areas of scientific researches:
                    Large scale impulsive solar processes, kinetic processes of quiet Sun
                    corona formation, software development and scientific preparation for
                    SECCHI on board of the NASA STEREO mission (co-investigation).


                    Course information:
                    The participants of the stream “Physics, Chemistry and Living Systems”
 Dr. Elena
                    learn about basic physical and chemical characteristics of celestial
 Podladchikova
                    bodies and their systems, get acquainted with basic methods of
                    experimental diagnostics of the Universe and modern techniques of
                    data analysis in astrophysics. Besides, this course gives the idea about
                    the structure of the Sun and the processes that occur on it. It is
                    commonly known that these processes are quite independent from
                    external influences and are determined solely by its own laws..


  Summer school AACIMP-2010                        http://summerschool.ssa.org.ua
Problems of Viral Infections’ Emergence and a
Role of Bioinformatics for Identify their Causes
Physics, Chemistry and Living Systems
                    Organizations:
                    The Institute of Veterinary Medicine of UAAS, Ukraine.
                    Member of Euroscience and Governing Board, European Plant
                    Biotechnology Network, Scientific Council of the Institute of Veterinary
                    Medicine (scientific secretary), etc.
                    Areas of scientific researches:
                    Viral infections, the development of biotechnologies anti-viral drugs, the
                    development of measures to combat and prevent the virus and associated
                    diseases, research of the impact of viruses on the cell's genome, research
                    of mutagenesis and antimutagenesis, ecology of viruses, the search and
                    the creation of new chemical antiviral agents.
 Doctor of
 Veterinary
 Science, PhD ,
                    Course information:
 Zinayida           Contemporary problems of virology, emergent infections, origin,
                    spreading, monitoring. Genetic analysis of pathogens, role of
 Klestova
                    bioinformatics in questions of phylogenesis, monitoring and
                    prognostication will be reviewed within the course.


   Summer school AACIMP-2010                          http://summerschool.ssa.org.ua
Chemoinformatics
Physics, Chemistry and Living Systems

                     Organizations:
                     Institute of Bioinformatics and Systems Biology, German Research
                     Center for Environmental Health, Munich, Germany.
                     Areas of scientific researches:
                     application of quantitative structure activity relationships (QSARs) for
                     the estimation of physico-chemical, biological properties and toxicity of
                     chemical compounds, development of methodological approaches to
                     estimate accuracy of predictions, algorithms of data storage.


                     Course information:
 PhD in bioorganic   The course is focused on application of achievements of
 chemistry, MSc in   chemoinformatics for solution of current environmental problems. The
 computer            course begins with overview of basic notions in chemoinformatics, its
 physics,            theoretical and practical importance for development of pharmaceutics
 Dr. Igor Tetko      and medicine. Several examples of practical application of
                     chemoinformatics in discovery of medicine and environment will be
                     given. At the course the lecturer tells about the latest achievements in
                     this scientific field.

   Summer school AACIMP-2010                          http://summerschool.ssa.org.ua
Neuron Synchronization and Representation
of Space and Time in Neural Networks
Physics, Chemistry and Living Systems
                    Organizations:
                    Department of Neuroinfomatics, Center for Optical Neural Technologies,
                    Scientific Research Institute for Systems Analysis, Russian Academy of
                    Sciences, Moscow, Russia.
                    Areas of scientific researches:
                    experimental and theoretical biophysics of different parts of nervous
                    system- little brain, brainstem, Ammon's horn and biophysics of cells,
                    neural systems, problems of general artificial intelligence.


                    Course information:
 Professor, Dr.,    The course is based on classical and modern works, that model and
 Witali L. Dunin-   analyze several features of neuronal systems operation. In particular,
 Barkowski          two aspects of information representation by impulse neuronal activity
                    are considered: pulse-frequency code and cooperative effects of
                    synchronized vs. desynchronized impulse activity of single neurons in
                    homogenous neural populations. The course is based on the latest
                    researches in this area.


   Summer school AACIMP-2010                         http://summerschool.ssa.org.ua
Brain-Computer Interface.
Approaches and Methods
Physics, Chemistry and Living Systems
                    Organizations:
                    CEA, Atomic Energy Center, Grenoble, France.

                    Areas of scientific researches:
                    Signal processing and pattern recognition: methods and algorithms of
                    signal processing, modeling and pattern recognition using the inverse
                    methods of nonlinear oscillation theory; algorithms of fast calculation for
                    real time analysis, neuronal signal processing, brain-computer interface.


                    Course information:
 PhD,               The course familiarizes students with main technologies, tasks and
                    methods in BCI systems. The lecturer highlights the main areas of
 Tatiana            development of invasive and non-invasive BCI systems, the approaches
 Aksenova           which are applied, mathematical methods and algorithms; tell about the
                    successful application of BCI systems in different spheres (particularly in
                    clinical medicine).




   Summer school AACIMP-2010                          http://summerschool.ssa.org.ua
Models of Synaptic Transmission
Physics, Chemistry and Living Systems

                    Organizations:
                    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany;
                    Bernstein Center for Computational Neuroscience, Berlin, Germany.
                    Areas of scientific researches:
                    Information processing, perception and primary analysis in nervous
                    system; cellular and subcellular training mechanisms; structure of
                    celebrum neural networks; types of cells in cerebral cortex, algorithms
                    and methods to analyze focal and impulse activity in cerebral cortex.


                    Course information:
 PhD,               The course gives an introduction into the principles of communication
 Dmitry             between neural cells via synapses. The lecturer presents basic
 Bibichkov          mathematical models of chemical synapses, models of short-term and
                    longterm plasticity; during the lecture the influence of synaptic
                    properties on information transmission between single cells and on
                    behavior of neural networks are discussed. Several examples illustrate
                    how these properties can be used to explain certain biologically
                    substantial phenomena.

   Summer school AACIMP-2010                        http://summerschool.ssa.org.ua
Neuron Connection with Computer in
Dynamic-Clamp Experiments
Physics, Chemistry and Living Systems
                    Organizations:
                    Ioffe Physical Technical Institute of Russian Academy of Sciences, Saint-
                    Petersburg, Russia.
                    Areas of scientific researches:
                    Biophysical models of separate neurons; development of records for
                    experimental intracellular measurements (Dynamic-Clamp); theory of
                    neuron population models; biophysically-detailed model of cortical
                    neural tissue, a model of visual cortex.

                    Course information:
                    This course represents biophysical detailed neuron models of the
PhD,
                    Hodgkin-Huxley type, their main properties and reductions. This
Dr. Anton Chizhov   knowledge allows controlling neuron in real time that gives new
                    possibilities for electrophysiological measurements and that is an
                    example of brain system interaction with computer. Proceeding to
                    consideration of statistical ensemble of neurons, population models of
                    various classes are demonstrated starting from exact models on basis of
                    probability distribution function finishing with simple models of a
                    frequency type.

  Summer school AACIMP-2010                         http://summerschool.ssa.org.ua
Methods and Tools for Detailed Modeling
of Neurons and Neural Networks
Physics, Chemistry and Living Systems
                      Organizations:
                      A. Kogan Research Institute for Neurocybernetics, Southern Federal
                      University, Rostov-on-Don, Russia.
                      Areas of scientific researches:
                      Information processing, perception and primary analysis in nervous
                      system; cellular and subcellular training mechanisms; structure of
                      celebrum neural networks; types of cells in cerebral cortex, algorithms
                      and methods to analyze focal and impulse activity in cerebral cortex.

                      Course information:
                      The main notions of neurobiology are presented in this course. An
 Senior researcher,   overview of mathematical methods which are used for neurons and
 PhD in technical     neural networks modeling are given. The attendees receive basic
 science,             knowledge on brain cells (neurons) and contacts among them
 Ruben Tikidji-       (synapses), biophysical and biochemical aspects of neuronal models as
 Hamburyan            well as review special software. Other courses of the stream “Physics,
                      Chemistry and Living Systems” devoted to contemporary neuroresearch
                      and neurotechnologies are a continuation of this course and are based
                      on the notions, methods and concepts delivered in it.

  Summer school AACIMP-2010                           http://summerschool.ssa.org.ua
Practical course
Methods and Tools for Detailed Modeling of Neurons and
Neural Networks
Physics, Chemistry and Living Systems
  Tutor: Senior researcher, PhD in technical science,
         Ruben Tikidji-Hamburyan




  Summer school AACIMP-2010                             http://summerschool.ssa.org.ua
Practical course
Methods and Tools for Detailed Modeling of Neurons and
Neural Networks
Physics, Chemistry and Living Systems
  Tutor: Senior researcher, PhD in technical science,
         Ruben Tikidji-Hamburyan




  Summer school AACIMP-2010                             http://summerschool.ssa.org.ua
Practical course
Methods and Tools for Detailed Modeling of Neurons and
Neural Networks
Physics, Chemistry and Living Systems
  Tutor: Senior researcher, PhD in technical science,
         Ruben Tikidji-Hamburyan




  Summer school AACIMP-2010                             http://summerschool.ssa.org.ua
Practical course
Methods and Tools for Detailed Modeling of Neurons and
Neural Networks
Physics, Chemistry and Living Systems
  Tutor: Senior researcher, PhD in technical science,
         Ruben Tikidji-Hamburyan




  Summer school AACIMP-2010                             http://summerschool.ssa.org.ua
Organizing committee. Contacts
Physics, Chemistry and Living Systems

  Responsible on a work with participants –
  Sandra Yaremchuk
  +38(093) 936 3332,
  +38(097) 115 9087.

  Technical support –
  Igor Stepanyan
  +38(095) 556 1562

  Student Science Association
  Room 299(15), build.#1
  +38(044) 454 9243

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Introductory Lecture to Physics, Chemistry and Living Systems Stream

  • 1. Physics, Chemistry and Living Systems Introductory lecture Speaker: Dr. Ruben Tikidji-Hamburyan Summer school AACIMP-2010, Kyiv, KPI, August, 4
  • 2. Main ideas of program formation Physics, Chemistry and Living Systems Actuality and novelty Diversity Quality of topics, fields, approaches, teaching methods, studying etc.
  • 3. Stream courses: Physics, Chemistry and Living Systems 1. Introduction to modern methods and tools for biologically plausible modeling of neurons and neural networks (Lectures - 4 h., Practice activity – 4 h.), Dr. R. Tikidji-Hamburyan 2. Brain–computer interface. Approaches and methods (3 h.), Dr. T. Aksenova 3. Problems of synchronization and presentation of space and time in neural networks (10 h.), Prof. Witali L. Dunin-Barkowski 4. Models of synaptic transmission (4 h.), Dr. D. Bibichkov 5. Neuron Connection With Computer in Dynamic-Clamp Experiments (2 h.), Dr. A. Chizhov 6. Models of Neuron Populations (2 h.), Dr. A. Chizhov 7. Urgent Questions of Virology (1 h.), Dr. Z. Klestova 8. Visual Cortex (3 h.), Dr. D. Bibichkov&Dr. A. Chizhov 9. Chemoinformatics (2 h.), Dr. I. Tetko 10. Experimental Diagnostics of Our Universe (2 h.), Dr. E. Podladchikova 11. Open Discussion : The Open Questions in Neuroscience (3 h) Total hours: 40
  • 4. Stream information Physics, Chemistry and Living Systems  Stream language: English  Stream rooms:  40(3), build.#1,  258 of build.#1 and 235 of build.#3 for practice work  Plenary lectures at the stream program:  Presentation of EURO XXV conference in Vilnius, Prof. L. Sakalauskas  P&G master-class on logistics  Innovation technologies of 3D-modelling, Materialize  The Open Questions in Neuroscience (Open Discussion), Conference hall of Scientific Park, build.#6, 11.08.10
  • 5. Physics, Chemistry and Living Systems Teachers and courses
  • 6. Countries and Universities Physics, Chemistry and Living Systems Southern Federal University, Max Planck Institute for Biophysical Rostov-on-Don, Rusiia Chemistry, Germany CEA, Atomic Energy Center, Ioffe Physical-Technical Institute of the Grenoble, France. Russian Academy of Sciences
  • 7. Countries and Universities Physics, Chemistry and Living Systems Royal Observatory of Belgium, Solar-Terrestrial Center of Excellence, Belgium. The Institute of Veterinary Medicine of UAAS, Ukraine. Institute of Bioinformatics and Systems Biology, German Research Center for Environmental Health, Munich, Germany
  • 8. Astrophysics Physics, Chemistry and Living Systems Organizations: Royal Observatory of Belgium, Solar-Terrestrial Center of Excellence, Belgium Areas of scientific researches: Large scale impulsive solar processes, kinetic processes of quiet Sun corona formation, software development and scientific preparation for SECCHI on board of the NASA STEREO mission (co-investigation). Course information: The participants of the stream “Physics, Chemistry and Living Systems” Dr. Elena learn about basic physical and chemical characteristics of celestial Podladchikova bodies and their systems, get acquainted with basic methods of experimental diagnostics of the Universe and modern techniques of data analysis in astrophysics. Besides, this course gives the idea about the structure of the Sun and the processes that occur on it. It is commonly known that these processes are quite independent from external influences and are determined solely by its own laws.. Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 9. Problems of Viral Infections’ Emergence and a Role of Bioinformatics for Identify their Causes Physics, Chemistry and Living Systems Organizations: The Institute of Veterinary Medicine of UAAS, Ukraine. Member of Euroscience and Governing Board, European Plant Biotechnology Network, Scientific Council of the Institute of Veterinary Medicine (scientific secretary), etc. Areas of scientific researches: Viral infections, the development of biotechnologies anti-viral drugs, the development of measures to combat and prevent the virus and associated diseases, research of the impact of viruses on the cell's genome, research of mutagenesis and antimutagenesis, ecology of viruses, the search and the creation of new chemical antiviral agents. Doctor of Veterinary Science, PhD , Course information: Zinayida Contemporary problems of virology, emergent infections, origin, spreading, monitoring. Genetic analysis of pathogens, role of Klestova bioinformatics in questions of phylogenesis, monitoring and prognostication will be reviewed within the course. Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 10. Chemoinformatics Physics, Chemistry and Living Systems Organizations: Institute of Bioinformatics and Systems Biology, German Research Center for Environmental Health, Munich, Germany. Areas of scientific researches: application of quantitative structure activity relationships (QSARs) for the estimation of physico-chemical, biological properties and toxicity of chemical compounds, development of methodological approaches to estimate accuracy of predictions, algorithms of data storage. Course information: PhD in bioorganic The course is focused on application of achievements of chemistry, MSc in chemoinformatics for solution of current environmental problems. The computer course begins with overview of basic notions in chemoinformatics, its physics, theoretical and practical importance for development of pharmaceutics Dr. Igor Tetko and medicine. Several examples of practical application of chemoinformatics in discovery of medicine and environment will be given. At the course the lecturer tells about the latest achievements in this scientific field. Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 11. Neuron Synchronization and Representation of Space and Time in Neural Networks Physics, Chemistry and Living Systems Organizations: Department of Neuroinfomatics, Center for Optical Neural Technologies, Scientific Research Institute for Systems Analysis, Russian Academy of Sciences, Moscow, Russia. Areas of scientific researches: experimental and theoretical biophysics of different parts of nervous system- little brain, brainstem, Ammon's horn and biophysics of cells, neural systems, problems of general artificial intelligence. Course information: Professor, Dr., The course is based on classical and modern works, that model and Witali L. Dunin- analyze several features of neuronal systems operation. In particular, Barkowski two aspects of information representation by impulse neuronal activity are considered: pulse-frequency code and cooperative effects of synchronized vs. desynchronized impulse activity of single neurons in homogenous neural populations. The course is based on the latest researches in this area. Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 12. Brain-Computer Interface. Approaches and Methods Physics, Chemistry and Living Systems Organizations: CEA, Atomic Energy Center, Grenoble, France. Areas of scientific researches: Signal processing and pattern recognition: methods and algorithms of signal processing, modeling and pattern recognition using the inverse methods of nonlinear oscillation theory; algorithms of fast calculation for real time analysis, neuronal signal processing, brain-computer interface. Course information: PhD, The course familiarizes students with main technologies, tasks and methods in BCI systems. The lecturer highlights the main areas of Tatiana development of invasive and non-invasive BCI systems, the approaches Aksenova which are applied, mathematical methods and algorithms; tell about the successful application of BCI systems in different spheres (particularly in clinical medicine). Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 13. Models of Synaptic Transmission Physics, Chemistry and Living Systems Organizations: Max Planck Institute for Biophysical Chemistry, Gottingen, Germany; Bernstein Center for Computational Neuroscience, Berlin, Germany. Areas of scientific researches: Information processing, perception and primary analysis in nervous system; cellular and subcellular training mechanisms; structure of celebrum neural networks; types of cells in cerebral cortex, algorithms and methods to analyze focal and impulse activity in cerebral cortex. Course information: PhD, The course gives an introduction into the principles of communication Dmitry between neural cells via synapses. The lecturer presents basic Bibichkov mathematical models of chemical synapses, models of short-term and longterm plasticity; during the lecture the influence of synaptic properties on information transmission between single cells and on behavior of neural networks are discussed. Several examples illustrate how these properties can be used to explain certain biologically substantial phenomena. Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 14. Neuron Connection with Computer in Dynamic-Clamp Experiments Physics, Chemistry and Living Systems Organizations: Ioffe Physical Technical Institute of Russian Academy of Sciences, Saint- Petersburg, Russia. Areas of scientific researches: Biophysical models of separate neurons; development of records for experimental intracellular measurements (Dynamic-Clamp); theory of neuron population models; biophysically-detailed model of cortical neural tissue, a model of visual cortex. Course information: This course represents biophysical detailed neuron models of the PhD, Hodgkin-Huxley type, their main properties and reductions. This Dr. Anton Chizhov knowledge allows controlling neuron in real time that gives new possibilities for electrophysiological measurements and that is an example of brain system interaction with computer. Proceeding to consideration of statistical ensemble of neurons, population models of various classes are demonstrated starting from exact models on basis of probability distribution function finishing with simple models of a frequency type. Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 15. Methods and Tools for Detailed Modeling of Neurons and Neural Networks Physics, Chemistry and Living Systems Organizations: A. Kogan Research Institute for Neurocybernetics, Southern Federal University, Rostov-on-Don, Russia. Areas of scientific researches: Information processing, perception and primary analysis in nervous system; cellular and subcellular training mechanisms; structure of celebrum neural networks; types of cells in cerebral cortex, algorithms and methods to analyze focal and impulse activity in cerebral cortex. Course information: The main notions of neurobiology are presented in this course. An Senior researcher, overview of mathematical methods which are used for neurons and PhD in technical neural networks modeling are given. The attendees receive basic science, knowledge on brain cells (neurons) and contacts among them Ruben Tikidji- (synapses), biophysical and biochemical aspects of neuronal models as Hamburyan well as review special software. Other courses of the stream “Physics, Chemistry and Living Systems” devoted to contemporary neuroresearch and neurotechnologies are a continuation of this course and are based on the notions, methods and concepts delivered in it. Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 16. Practical course Methods and Tools for Detailed Modeling of Neurons and Neural Networks Physics, Chemistry and Living Systems Tutor: Senior researcher, PhD in technical science, Ruben Tikidji-Hamburyan Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 17. Practical course Methods and Tools for Detailed Modeling of Neurons and Neural Networks Physics, Chemistry and Living Systems Tutor: Senior researcher, PhD in technical science, Ruben Tikidji-Hamburyan Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 18. Practical course Methods and Tools for Detailed Modeling of Neurons and Neural Networks Physics, Chemistry and Living Systems Tutor: Senior researcher, PhD in technical science, Ruben Tikidji-Hamburyan Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 19. Practical course Methods and Tools for Detailed Modeling of Neurons and Neural Networks Physics, Chemistry and Living Systems Tutor: Senior researcher, PhD in technical science, Ruben Tikidji-Hamburyan Summer school AACIMP-2010 http://summerschool.ssa.org.ua
  • 20. Organizing committee. Contacts Physics, Chemistry and Living Systems Responsible on a work with participants – Sandra Yaremchuk +38(093) 936 3332, +38(097) 115 9087. Technical support – Igor Stepanyan +38(095) 556 1562 Student Science Association Room 299(15), build.#1 +38(044) 454 9243