The document discusses different methods for representing negative numbers in binary, including signed bit representation and two's complement representation. Two's complement is described as a better method as it avoids having two representations for zero. The key aspects of two's complement are explained, such as how to find the two's complement of a number by flipping its bits and adding one. Examples are provided to illustrate how negative numbers are represented using two's complement. The document also discusses the range of integers that can be stored using different numbers of bytes with two's complement representation.