This document discusses an advanced approach to medical image compression using the SPIHT coding algorithm, emphasizing the importance of preserving diagnostic information while reducing image size. It introduces a novel technique focusing on the region of interest (ROI) in medical images, enhancing compression efficiency and transmission bandwidth. The proposed Advanced SPIHT (ASPIHT) algorithm demonstrates improved performance in terms of compression ratio and peak signal-to-noise ratio compared to conventional SPIHT methods.