The document discusses running MariaDB across multiple data centers. It begins by outlining the need for multi-datacenter database architectures to provide high availability, disaster recovery, and continuous operation. It then describes topology choices for different use cases, including traditional disaster recovery, geo-synchronous distributed architectures, and how technologies like MariaDB Master/Slave and Galera Cluster work. The rest of the document discusses answering key questions when designing a multi-datacenter topology, trade-offs to consider, architecture technologies, and pros and cons of different approaches.