The lecture notes by Dr. Piyush Charan focus on quantization techniques for data compression, particularly vector quantization (VQ) as a method for lossy compression. It discusses the advantages of VQ over scalar quantization, the Linde-Buzo-Gray algorithm, and tree-structured vector quantization methods, emphasizing their application in multimedia data compression. Key points include the importance of an optimal codebook for performance and the benefits of structured approaches to reduce complexity and improve efficiency in quantization.