This document provides an overview of designing complex applications using HTML5 and KnockoutJS. It discusses HTML5 and why it is useful, introduces JavaScript and frameworks like KnockoutJS and SammyJS that help manage complexity. It also summarizes several JavaScript libraries and patterns including the module pattern, revealing module pattern, and MV* patterns. Specific libraries and frameworks discussed include RequireJS, AmplifyJS, UnderscoreJS, and LINQ.js. The document concludes with a brief mention of server-side tools like ScriptSharp.